1-Azido-3-iodopropane
描述
1-Azido-3-iodopropane is a useful research compound. Its molecular formula is C3H6IN3 and its molecular weight is 211.00 g/mol. The purity is usually 95%.
BenchChem offers high-quality this compound suitable for many research applications. Different packaging options are available to accommodate customers' requirements. Please inquire for more information about this compound including the price, delivery time, and more detailed information at [email protected].
科学研究应用
Applications in Click Chemistry
Click chemistry refers to a set of powerful reactions that allow for the rapid and efficient formation of covalent bonds. 1-Azido-3-iodopropane is particularly useful in:
- Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC) : This reaction involves the reaction of azides with terminal alkynes to form 1,2,3-triazoles. The use of this compound facilitates the synthesis of various triazole derivatives, which have applications ranging from drug development to materials science .
| Reaction Type | Description | Applications |
|---|---|---|
| CuAAC | Reaction between azides and alkynes | Drug synthesis, materials science |
| Strain-Promoted Azide-Alkyne Cycloaddition (SPAAC) | Copper-free alternative for biological applications | Bioconjugation in living systems |
Bioconjugation and Protein Labeling
This compound is employed for bioconjugation processes, particularly in labeling proteins with fluorescent tags. For instance, bovine serum albumin (BSA) can be modified with azide groups using this compound, allowing for subsequent labeling with fluorophores through click chemistry . This method is advantageous due to its specificity and efficiency.
Case Study: Fluorescent Labeling of Proteins
A study demonstrated the use of this compound to label BSA with fluorescent dyes. The process involved:
- Treating BSA with this compound in a TRIS buffer.
- Irradiating the mixture to facilitate the reaction.
- Analyzing the resulting fluorescently labeled protein using spectroscopic methods.
This technique highlights the potential for real-time imaging and tracking of proteins in biological systems .
Pharmaceutical Applications
The compound has been explored for its potential in developing new pharmaceuticals. Its ability to form stable triazole linkages makes it a candidate for synthesizing bioactive compounds.
Case Study: Antifungal Activity
Research has indicated that derivatives synthesized from this compound exhibit antifungal properties. A series of compounds were prepared through click chemistry involving this azide, leading to promising results against various fungal strains .
| Compound | Activity | Target Organisms |
|---|---|---|
| Triazole Derivative A | Moderate | Candida albicans |
| Triazole Derivative B | High | Aspergillus niger |
Material Science Applications
In material science, this compound is utilized for modifying surfaces and creating functional materials. Its reactivity allows for the incorporation of azide functionalities into polymers, which can then undergo click reactions to create crosslinked networks or functionalized surfaces.
Case Study: Surface Functionalization
A study demonstrated the functionalization of polymer surfaces with azide groups using this compound, followed by subsequent reactions with alkyne-functionalized compounds. This approach enabled the creation of bioactive surfaces suitable for tissue engineering applications .
属性
分子式 |
C3H6IN3 |
|---|---|
分子量 |
211.00 g/mol |
IUPAC 名称 |
1-azido-3-iodopropane |
InChI |
InChI=1S/C3H6IN3/c4-2-1-3-6-7-5/h1-3H2 |
InChI 键 |
GTBCENNLSAZFSM-UHFFFAOYSA-N |
规范 SMILES |
C(CN=[N+]=[N-])CI |
产品来源 |
United States |
体外研究产品的免责声明和信息
请注意，BenchChem 上展示的所有文章和产品信息仅供信息参考。 BenchChem 上可购买的产品专为体外研究设计，这些研究在生物体外进行。体外研究，源自拉丁语 "in glass"，涉及在受控实验室环境中使用细胞或组织进行的实验。重要的是要注意，这些产品没有被归类为药物或药品，他们没有得到 FDA 的批准，用于预防、治疗或治愈任何医疗状况、疾病或疾病。我们必须强调，将这些产品以任何形式引入人类或动物的身体都是法律严格禁止的。遵守这些指南对确保研究和实验的法律和道德标准的符合性至关重要。
