molecular formula C10H22NaO B8452104 Sodium t-amyl oxide

Sodium t-amyl oxide

Cat. No.: B8452104
M. Wt: 181.27 g/mol
InChI Key: UIIJZQVROQHLAP-UHFFFAOYSA-N
Attention: For research use only. Not for human or veterinary use.
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Description

Sodium t-amyl oxide is a useful research compound. Its molecular formula is C10H22NaO and its molecular weight is 181.27 g/mol. The purity is usually 95%.
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Scientific Research Applications

Organic Synthesis

Sodium t-amyl oxide serves as a strong base in organic reactions, facilitating the deprotonation of weak acids. This property is essential for forming carbon-carbon bonds, which are crucial in synthesizing complex organic molecules. Its role in organic synthesis can be summarized as follows:

Application Description
DeprotonationActs as a strong base to deprotonate weak acids.
Carbon-Carbon Bond FormationEnables the synthesis of various organic compounds through nucleophilic substitution and elimination reactions.
N-CyanationUsed in the N-cyanation of secondary amines, which is vital for producing pharmaceutical intermediates .

Polymer Chemistry

In polymer chemistry, this compound is utilized to synthesize polyolefins, which are essential for producing plastics and elastomers with enhanced properties. Its applications include:

Application Description
PolymerizationFacilitates the polymerization process to create high-performance materials.
Material PropertiesEnhances the mechanical and thermal properties of polymers .

Pharmaceutical Development

This compound plays a critical role in pharmaceutical development by acting as a reagent in the synthesis of drug intermediates. Its applications include:

Application Description
Drug SynthesisAids in synthesizing active pharmaceutical ingredients (APIs) through various chemical transformations.
Intermediate ProductionServes as a precursor for compounds used in therapeutic formulations .

Analytical Chemistry

In analytical chemistry, this compound enhances the sensitivity and selectivity of assays, making it valuable for quality control processes. Its contributions include:

Application Description
Assay EnhancementImproves detection limits and specificity in chemical analyses.
Quality ControlUsed in various assays to ensure compliance with regulatory standards .

Environmental Applications

This compound has potential applications in environmental remediation, particularly in breaking down hazardous substances through chemical reactions. Its role includes:

Application Description
Contaminant RemediationUtilized to degrade pollutants in contaminated sites through chemical reactions .

Case Study 1: Organic Synthesis

A study demonstrated the use of this compound in synthesizing complex molecules such as alkaloids and terpenes through deprotonation reactions that facilitated carbon-carbon bond formation.

Case Study 2: Pharmaceutical Development

Research highlighted this compound's effectiveness in synthesizing pharmaceutical intermediates for anti-inflammatory drugs, showcasing its importance in drug discovery and development processes.

Case Study 3: Environmental Remediation

An investigation into the use of this compound for remediating soil contaminated with heavy metals showed promising results, indicating its potential for breaking down toxic substances effectively.

Properties

Molecular Formula

C10H22NaO

Molecular Weight

181.27 g/mol

InChI

InChI=1S/C10H22O.Na/c1-7-9(3,4)11-10(5,6)8-2;/h7-8H2,1-6H3;

InChI Key

UIIJZQVROQHLAP-UHFFFAOYSA-N

Canonical SMILES

CCC(C)(C)OC(C)(C)CC.[Na]

Origin of Product

United States

Synthesis routes and methods I

Procedure details

860 mg of sodium were added to 18 ml of tertiary amylalcohol-absolute toluene (1:1), and the mixture was refluxed for 5 hours. Then, the reaction mixture was condensed to dryness, whereby sodium tertiary amyloxide was obtained. 20 ml of absolute toluene and 1.09 g of 1,2,3,4-tetrahydro-1-(3-methoxycarbonylpropyl)-2-benzyl-β-carboline were added to said sodium tertiary amyloxide under ice-cooling, and the mixture was stirred at the same temperature for 3 hours. After the reaction was completed, ethyl acetate was added to the reaction mixture. Said mixture was washed with an aqueous saturated sodium chloride solution, dried and then condensed. The residue thus obtained was purified by silica gel chromatography (Solvent: chloroform), and then recrystallized from a mixture of methanol and isopropyl ether, whereby 300 mg of 1,2,3,3a,4,5,6,7-octahydro-3-benzyl-7-oxo-azepino[1,2,3-lm]-β-carboline were obtained. Yield: 30.3%
Quantity
860 mg
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18 mL
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Reaction Step One

Synthesis routes and methods II

Procedure details

Tert-amyl alcohol was sent as a first fluid from the center at a ratio of supply pressure/back pressure of 0.40 MPa/0.25 MPa, a rotation speed of 1000 rpm, and a sending temperature of 120° C., and sodium was introduced as a second fluid at 103° C. into a space between the processing surfaces at 10 mL/min. The first fluid and the second fluid were mixed in a thin film fluid, and then a solution obtained after processing was discharged from the space between the processing surfaces at 19 mL/min. As a result, a solution of sodium t-amyl oxide and t-amyl alcohol was obtained.
Quantity
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Reaction Step One
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